Proteins phosporylated in HCT116 cells (colon cancer) upon p53 [GeneID=7157] activation.
| PAG Title | Proteins phosporylated in HCT116 cells (colon cancer) upon p53 [GeneID=7157] activation. |
| PAG ID | MAX002363 |
| Type | A |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modifications may contribute to p53-mediated tumor suppression. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 155 |
| Information Content | Rich |
| Other IDs | M1333 |
| Base PAG ID | MAX002363 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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